Knowledge Base for Investigators

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Knowledge Base for Patients

Circle Settings

What is Circle? One or more users who agree to share an observational protocol and resulting observations, according to the terms established by the circle administrator. Circles enable one or more users to selectively aggregate, benchmark and report upon data applied against a shared observational protocol.

Circle Name

You’re absolutely free to use any Circle name. However, we suggest you try to pick a specific name that will help your current and prospective circle members differentiate your circle from others.

What you can base on while naming your circle (some ideas to include in the Circle name):


Every circle has an associated pathology (indication) and treatment. So, we recommend you to create your circle/s according to the principle 1 circle=1 pathology.


So, if you want to collect data around Knee OA and Hip OA, we recommend you create two different circles.

Circle Types

In PHI circles you and your circle members will share actual patient cases, including protected health information. This is most useful for team-based care.

Choose Non-PHI if you are looking to share de-identified, aggregated clinical data. All members can review and benchmark this data through the report builder, but cannot identify a single user's case or PHI. Best used for external studies and multi-site collaboration.


Sponsorship means financial and administrative responsibility for a circle.

A sponsor can be a User or Non-User.

Sponsor benefits include:

Observational Protocol

Observational Protocol is the core of any circle. This determines the observational protocol to be used by all circle members, helping to standardize all aggregated cases. You have the ability to use the already existing observational protocol for your circle or request your own before circle creation.

Observational Protocols can be circle-specific and subscriber-specific, which means that you can create your own protocol based on the common circle protocol but adding/removing the questions you don’t need.

Contact your account manager to learn more about observational protocol creation.


Note: 1 circle = 1 treatment description and 1 indication (pathology) description.

Includes the description of the treatment performed and the reason/basis for its choice.

This information is displayed in the patient report so while adding your own descriptions to the library we recommend you use plain, simple language to make reports clear for your patients.

We have a large library of treatments and indications (pathologies). Just search for the required one by treatment/indication name while creating a circle. All the descriptions are general/common for all users. If you want to add any specific description of the treatment/indication or any treatment/pathology we don’t have in our inCytes library, please contact your account manager.


PRP Injection

Your blood contains self-healing properties. For injuries ranging from tiny paper cuts to large ulcers, your platelets naturally activate--clumping together to stop bleeding and begin the healing process. Platelets also secrete "growth factors," each of which plays a role in promoting cell growth, healing, differentiation, and maturation. Regenerative medicine supercharges your blood's own self-healing capabilities. By removing the red blood cells from your blood sample and then concentrating the platelets, a "platelet-rich plasma" (PRP) is created. Studies have found that PRP applied to injured areas promotes quicker and more effective healing in wide-ranging applications from sports medicine to cosmetic surgery. Blood naturally separates into its different components over time, but to speed the process for safe clinical use, several manufacturers make devices to more quickly separate it. The devices incorporate centrifuges, which spin liquids at high speeds to separate their components by density. To create PRP, typically the first centrifugation separates the red blood cells from the sample and later centrifugations concentrate the platelets.


Knee Osteoarthritis

Osteoarthritis is a common and chronic condition that impacts joints such as the knee. In healthy joints, cartilage covers the ends of bones and keeps them gliding seamlessly. However, in osteoarthritis, the cartilage breaks down, causing pain, stiffness, and other symptoms. Osteoarthritis can also cause damage ranging from bone spurs to altering the shape of bone ends. X-rays are usually part of the diagnostic process.

Data Ownership

We have more options when it comes to determining who sees PHI and who sees aggregated Circle Data. This allows for Circles to accommodate a broader range of collaborative, study, trial and other uses. See more.

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